Title: Assessing the Global Impact of Histone Acetylations on Gene Expression in Yeast Abstract: Gene activities in eukaryotic cells are regulated by the concerted action of transcription factors and the chromatin structure. Saccharomyces cerevisiae (budding yeast) contains at least 14 lysines residues at four different core histone proteins that can be acetylated. The combined effect of various acetylation sites is still poorly understood. In this talk, I will present an integrative approach combining information from acetylation, nucleosome occupancy, gene expression, and sequence information to systematically investigate the regulatory code of histone acetylation in Saccharomyces cerevisiae. The talk is based on joint work with Guo-Cheng Yuan, Wenxuan Zhong and Jun S. Liu. |