Sheng Zhong, a new faculty member in Bioengineering at UIUC, will be our first presenter. The abstract for his talk appears below: Slide set [PowerPoint] Current Topics in Computational Biology Sheng Zhong, Dept of Bioengineering, UIUC Computational Biology has evolved rapidly from a tool into a discipline. Huge amounts of genomic data, including genome sequence, microarray data and a lot of others, have been produced with the hope to understand fundamental questions related to human health. Computational developments that utilize genomic data to interrogate human health related problems are lacking behind the speed of data generation. Better algorithms and computational tools on machine learning, scientific computing, intelligence system, data management and information retrieval are in great demand. How these algorithms and tools should be developed to interrogate the important biological and biomedical questions is the art that is open to discuss in this lecture. Two biological questions and their related genomic data are going to be discussed. 1) How do stem cells work? 2) What causes cancer? In detail, can we computationally identify gene clusters based on gene expression profiles that best represent the functional relationship among genes? What is the gene regulatory network that initiates stem cell differentiation, or cancer formation? How do we decipher the relevant DNA sequence code so as to understand the genetic bases of cancer? Background Reading: 1. BBC News on stem cells: http://news.bbc.co.uk/2/hi/science/nature/4155016.stm Also related stem cell news on the right panel of the browser. 2. Forbes's survey of venture capital on stem cells http://www.forbes.com/newsletter/2004/11/01/cz_sg_1101soapbox.htm 3. Science: Joining Forces for Brain Tumor Research http://www.sciencemag.org/cgi/content/full/309/5731/32b Scientific Reading: 1. Microarray study on stem cells. http://www.sciencemag.org/cgi/content/abstract/298/5593/597 2. Brain tumor microarray study http://www.nature.com/nature/journal/v415/n6870/full/415436a_fs.html
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