What is NMPDR?

NMPDR is a Bioinformatics Resource Center that provides the advanced bioinformatics environment needed to identify genetic polymorphisms correlated with pathogenicity, drug resistance, morbidity, and infectivity. NMPDR is funded by the National Institute of Allergy and Infectious Disease (NIAID) to support research in biodefense, emerging infectious diseases, and re-emerging pathogens. NMPDR is both a central repository for a wide variety of scientific data on these pathogenic microorganisms and a platform for software tools that support investigator-driven data analysis.

NMPDR employs a strategy of subsystems annotation to provide researchers with corrected functional annotations in a structured biological context. More than 500 distinct subsystems have been developed to describe central and secondary metabolism, complex structures, and virulence or other phenotypes. NMPDR includes all essentially complete, public genomes that provide a rich context for comparative analysis. All genomes are queried by searching from the NMPDR home page. The core pathogens of NMPDR are each presented on an organism page that will limit the search to that set of genomes. The core pathogens are the Campylobacters, Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and the pathogenic Vibrios.